Research Article
Synthesis of Some New Azetidinone Derivatives Containing Aryl Sulfonyloxy Group
H.S. PATEL* and H.D. DESAI
ABSTRACT
Some novel azetidinone derivatives containing aryl sulfonyloxy group have been prepared. The 4-sulfonyloxy aniline derivative (2) has been prepared by reaction of 4-nitro phenol (sodium salt) with N-acetyl sulfanilyl chloride (ASC) followed by hydrolysis by ethanolic HCl. This compound (2) undergoes facile condensation reaction with aromatic aldehydes to yield different Schiff’s bases (3a-h). Cyclocondensation of compounds (3a-h) with chloro acetyl chloride yields different 2-azetidinone derivatives (4a-h).
Received 23 April 2004; Accepted 9 June 2004